Bioidentical hormone replacement therapy treatments are based on evidence-based research.

 

Effective treatments for age-related sleep disturbances. “The link between obesity and disease of aging has been confirmed in studies. These experiments provide powerful evidence that visceral fat tissue has a direct effect on age-associated insulin resistance. The increase in visceral fat tissue in older persons is associated with decreases in the serum levels of estrogen, testosterone, and growth hormone”: Link

 

Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. “DHEA replacement could play a role in prevention and treatment of the metabolic syndrome associated with abdominal obesity”: Link

 

Male – Hormone Therapy

Current status of testosterone replacement therapy in men. “Deficiency may include reduced body hair, decreased libido, erectile dysfunction, infertility, osteoporosis, and depressed mood”. “The most accurate indicator of hypogonadism is the concentration of testosterone that is not bound to sex hormone binding globulin which is the bioavailable or free testosterone”. “Benefits of androgen replacement therapy include increased energy, hematocrit, muscle mass, strength and stamina, increased ability to perform more physically demanding tasks, and an overall increase in the sense of well-being, confidence and motivation”. “Bone mineral density is increased by testosterone replacement. Improved libido and sexual function… frequency of erection and ejaculation”Link

 

Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. “Hemoglobin A1c, fasting plasma glucose, HDL-cholesterol, triglyceride concentrations, and the waist circumference improved with testosterone therapy”: Link

 

Longitudinal evaluation of serum androgen levels in men with and without prostate cancer : Link

 

Testosterone and depression: systematic review and meta-analysis. “Testosterone therapy may have an antidepressant effect in depressed patients, especially those with hypogonadism”: Link

 

Risks of Testosterone-Replacement Therapy and Recommendations for Monitoring ” It is reassuring that as far as we can determine, no testosterone associated thromboembolic events have been reported to date.” : Link

 

Endogenous sex hormone levels and cognitive function in aging men. Is there an optimal level? “Higher testosterone (T) levels are associated with better cognitive performance in the oldest age category” : Link

 

 

Female- Hormone Therapy

Brains, hormones, and more behind women’s aging. “Traditionally, this aging process has been considered to be physiological and unavoidable but in recent years an increasing number of people are not willing to accept the grim stereotypical of aging as an unalterable process of decline and loss. Hormones are partly responsible for this change in attitude” Biomedicina 2000 Jan;Vol 3( 1):6-7.

 

Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. “Higher endogenous DHEAS levels are independently and favorably associated with executive function, concentration, and working memory”: Link

 

Thyroid Hormone – “Normal is not Optimal”

Combined Therapy with Levothyroxine and Liothyronine in Two Ratios, Compared with Levothyroxine Monotherapy in Primary Hypothyroidism: a Double-Blind, Randomized, Controlled Clinical Trial. “Patients preferred combined LT4/LT3 therapy to usual LT4 therapy, but changes in mood, fatigue, well-being, and neurocognitive functions could not satisfactorily explain why the primary outcome was in favor of LT4/LT3 combination therapy. Decrease in body weight was associated with satisfaction with study medication”: Link

 

Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study: Link

 

Thyroid Replacement Therapy and Heart Failure. “A growing body of evidence suggests that TH (thyroid hormone) dysfunction may play an important role in the progression to dilated HF (heart failure)”: Link

 

TSH may not be a good marker for adequate thyroid hormone replacement therapy. “TSH levels used to monitor substitution, mostly regulated by intracellular T3 in the pituitary, may not be such a good indicator of adequate thyroid hormone action in all tissues. The co-administration of T3 may prove more effective in this respect, provided novel suitable preparations are developed”: Link